Personalized medicine aims to tailor disease prevention, diagnosis, and treatment to individuals on the basis of their genes, lifestyle and environments. Patient and interest organizations may potentially play an important role in the realization of PM. This paper investigates the views and perspectives on PM of a variety of PIOs. Semi-structured telephone interviews were conducted among leading representatives of 13 PIOs located in Europe and North-America. The data collected were analysed using a conventional content analysis approach. The PIO representatives supported (...) the realization of PM but feared that many financial, structural and organizational challenges may delay its realization. They encouraged strategies to modernize drug licencing mechanisms, develop research and data sharing infrastructures, and educate patients and health care professionals in PM. Notably, they emphasized the importance of developing PM in an equitable way and taking into consideration the patients’ needs, values and personal situation. Despite varying levels of awareness regarding PM, the PIO representatives expressed willingness to engage in the PM agenda and recommended that PIOs work closely with policy-makers to design PM in a way that truly addresses the needs and concerns of patients. PIOs have the potential to become central drivers of the PM agenda. Collaborations should be further developed between PIOs, researchers, drug developers and health care authorities. (shrink)

The historical context of body and tissue donation is deeply problematic, with patriarchal and colonial narratives. The contemporary context of molecular and genetic biology further complicates issues of bodily donation through narratives of abstraction and extraction. As practitioners working outside the conventional boundaries of scientific study learn the tools and techniques to extract and use bodily materials, they are also learning and challenging the procedures and processes. This article approaches questions of bodily donation through the edited transcript of a conversation (...) between artists who regularly use body fluids and cellular bodily materials in their practice, moderated by Louise Mackenzie and Ilke Turkmendag as part of the Taboo–Transgression–Transcendence in Art & Science Conference held online with the support of the University of Applied Arts, Vienna, 2020. The panel challenged the ethical and conceptual assumptions made in biotechnological research and reconsidered where the boundaries of the body lie, what ‘authority’ research carries and what choices researchers make when using the bodies of others. The transcribed conversation addresses taboos of the female body, specifically menstruation, the commodification of tissue from female human bodies, human milk politics and questions biopolitical treatment of the female body. The full, unedited panel conversation, including questions from the audience, and an accompanying video of edited interviews with panellists, is available online at https://www.loumackenzie.com/offering-the-body. (shrink)

Growing inequality and its implications for democratic polity suggest that corporate social responsibility has not proved itself in twenty-first century business, largely as it lacks clear criteria of demarcation for businesses to follow. Today the problem is viewed by many commentators as an ethical challenge to business itself. In response to this challenge, we begin by examining Porter and Kramer’s :64–77, 2011) call for a shift from a social responsibility to a shared value framework and the need to respond to (...) the problem of the ‘separation thesis’ between business and ethics :89–118, 1996; Harris and Freeman, Bus Ethics Q 18:541–548, 2008). We identify the eighteenth century economist and philosopher Adam Smith in his book The Theory of Moral Sentiments as a source for an ethical approach to business. Building on his central concept of ‘sympathy’, we introduce the idea of the Impartial Spectator Test, which we argue builds on traditional stakeholder perspectives and which provides an objective route to ethical criteria of demarcation. We conclude by assessing how this approach adds to the existing debate around social responsibility and shared value. (shrink)

In the UK, as elsewhere in the world, the global financial crisis has focused attention on the cost of public services and the need to reduce expenditure, not least in respect of higher education. This, however, raises a set of prior questions: What kind of society do we want? What is important to democratic society? What kind of higher education is desirable? The article takes Alasdair MacIntyre's critique of what he calls liberal capitalist society as a starting point for considering (...) questions concerning the kind of higher education that would be valuable and relevant to a healthy democratic society. His thesis is outlined and the implications of this for the university set out. The article examines MacIntyre's notion of community, which he elaborates in relation to medieval religious worldviews, and argues that whilst his conceptualisation is more intellectually and educationally coherent than some others, it is ultimately too restrictive. The article argues instead for a recognition, within education, of what is uncommon. This may open greater possibilities for keeping alive the serious questions that we must constantly attend to, beyond and within our communities, secular or religious. (shrink)

Property rights are the rules governing ownership in society. This Element offers an analytical framework to understand the origins and consequences of property rights. It conceptualizes of the political economy of property rights as a concern with the follow questions: What explains the origins of economic and legal property rights? What are the consequences of different property rights institutions for wealth creation, conservation, and political order? Why do property institutions change? Why do legal reforms relating to property rights such as (...) land redistribution and legal titling improve livelihoods in some contexts but not others? In analyzing property rights, the authors emphasize the complementarity of insights from a diversity of disciplinary perspectives, including Austrian economics, public choice, and institutional economics, including the Bloomington School of institutional analysis and political economy. (shrink)

Vaccines, when available, will prove to be crucial in the fight against Covid-19. All societies will face acute dilemmas in allocating scarce lifesaving resources in the form of vaccines for Covid-19. The author proposes The Value of Lives Principle as a just and workable plan for equitable and efficient access. After describing what the principle entails, the author contrasts the advantage of this approach with other current proposals such as the Fair Priority Model.

Deepfakes and other forms of synthetic media are widely regarded as serious threats to our knowledge of the world. Various technological responses to these threats have been proposed. The reactive approach proposes to use artificial intelligence to identify synthetic media. The proactive approach proposes to use blockchain and related technologies to create immutable records of verified media content. I argue that both approaches, but especially the reactive approach, are vulnerable to a problem analogous to the ancient problem of the criterion—a (...) line of argument with skeptical implications. I argue that, while the proactive approach is relatively resistant to this objection, it faces its own serious challenges. In short, the proactive approach would place a heavy burden on users to verify their own content, a burden that is exacerbated by and is likely to exacerbate existing inequalities. (shrink)

An argument that moral functioning is immeasurably complex, mediated by biology but not determined by it. Throughout history, humanity has been seen as being in need of improvement, most pressingly in need of moral improvement. Today, in what has been called the beginnings of “the golden age of neuroscience,” laboratory findings claim to offer insights into how the brain “does” morality, even suggesting that it is possible to make people more moral by manipulating their biology. Can “moral bioenhancement”—using technological or (...) pharmaceutical means to boost the morally desirable and remove the morally problematic—bring about a morally improved humanity? In The Myth of the Moral Brain, Harris Wiseman argues that moral functioning is immeasurably complex, mediated by biology but not determined by it. Morality cannot be engineered; there is no such thing as a “moral brain.” Wiseman takes a distinctively interdisciplinary approach, drawing on insights from philosophy, biology, theology, and clinical psychology. He considers philosophical rationales for moral enhancement, and the practical realities they come up against; recent empirical work, including studies of the cognitive and behavioral effects of oxytocin, serotonin, and dopamine; and traditional moral education, in particular the influence of religious thought, belief, and practice. Arguing that morality involves many interacting elements, Wiseman proposes an integrated bio-psycho-social approach to the consideration of moral enhancement. Such an approach would show that, by virtue of their sheer numbers, social and environmental factors are more important in shaping moral functioning than the neurobiological factors with which they are interwoven. (shrink)

Selective serotonin reuptake inhibitors (SSRIs) have gained a degree of prominence across recent moral enhancement literature as a possible intervention for dealing with antisocial and aggressive impulses. This is due to serotonin's purported capacity to modulate persons’ averseness to harm. The aim of this article is to argue that the use of SSRIs is not something worth getting particularly excited about as a practicable intervention for moral enhancement purposes, and that the generally uncritical enthusiasm over serotonin's potential as a moral (...) enhancer is a consequence of the paucity of viable options for envisaging practicable moral enhancement interventions. While there are many conceptual issues raised by the idea of moral enhancement generally, and by the idea of serotonin as a morally affective agent, the aim here is to look at practical concerns. It is argued that SSRIs do not, nor cannot in the reasonably foreseeable future, be made to work as a reliably safe or reliably effective means for moral enhancement, even within the very limited remit of treating “reactive” aggression. SSRIs might be effective as a limited and partial mental health intervention (even this is questionable), but not as a generally effective moral enhancement technology. (shrink)

Psychological-epistemic accounts take scientific progress to consist in the development of some psychological-epistemic attitude. Disagreements over what the relevant attitude is – true belief, knowledge, or understanding – divide proponents of thesemantic,epistemic,andnoeticaccounts of scientific progress, respectively. Proponents of all such accounts face a common challenge. On the face of it, only individuals have psychological attitudes. However, as I argue in what follows, increases in individual true belief, knowledge, and understanding are neither necessary nor sufficient for scientific progress. Rather than being (...) fatal to the semantic, epistemic, and noetic accounts, this objection shows that these accounts are most plausible when they take the psychological states relevant to scientific progress to be states of communities, rather than individuals. I draw on recent work in social epistemology to develop two ways in which communities can be the bearers of irreducible psychological-epistemic states. Each way yields a strategy by which proponents of one of the psychological-epistemic accounts might attempt to account for the social dimensions of scientific progress. While I present serious reasons for concern about the first strategy, I argue that the second strategy, at least, offers a promising path forward for a psychological-epistemic account of scientific progress. (shrink)

Deepfakes pose a multi-faceted threat to the acquisition of knowledge. It is widely hoped that technological solutions—in the form of artificially intelligent systems for detecting deepfakes—will help to address this threat. I argue that the prospects for purely technological solutions to the problem of deepfakes are dim. Especially given the evolving nature of the threat, technological solutions cannot be expected to prevent deception at the hands of deepfakes, or to preserve the authority of video footage. Moreover, the success of such (...) technologies depends on institutional trust that is in short supply. Finally, outsourcing the discrimination between the real and the fake to automated, largely opaque systems runs the risk of undermining epistemic autonomy. (shrink)

The defensibility of the extended mind thesis (EMT) is often thought to hinge on the possibility of extended selves. I argue that the self cannot extend and consider the ramifications of this finding, especially for EMT. After an overview of EMT and the supposed cruciality of the extended self to the defensibility of the former thesis, I outline several lines of argument in support of the possibility of extended selves. Each line of argument appeals to a different account of diachronic (...) personal identity. I argue that no such argument for extended selves succeeds, as no account of diachronic personal identity is both plausible and supports the view that the self can extend. Next, I consider three objections that, if successful, would undercut the preceding argument that the self cannot extend. I conclude by reflecting on the implications of the conclusion that the self cannot extend, including the prospects for EMT. (shrink)

Are the properties of communicative acts grounded in the intentions with which they are performed, or in the conventions that govern them? The latest round in this debate has been sparked by Ernie Lepore and Matthew Stone (2015), who argue that much more of communication is conventional than we thought, and that the rest isn’t really communication after all, but merely the initiation of open-ended imaginative thought. I argue that although Lepore and Stone may be right about many of the (...) specific cases they discuss, their big-picture, conventionalist conclusions don’t follow. My argument focuses on four phenomena that present challenges to conventionalist accounts of communication: ambiguity, indirect communication, communication by wholly unconventional means, and convention acquisition. (shrink)

Critics of virtue reliabilism allege that the view cannot account for testimonial knowledge, as the acquisition of such knowledge is creditable to the testifier, not the recipient's cognitive abilities. I defend virtue reliabilism by attending to empirical work concerning human abilities to detect sincerity, certainty, and seriousness through bodily cues and properties of utterances. Then, I consider forms of testimony involving books, newspapers, and online social networks. I argue that, while discriminatory abilities directed at bodily cues and properties of utterances (...) are impotent in the face of such testimony, alternative abilities facilitate the acquisition of knowledge from these sources. (shrink)

In this article, I defend a version of ontological pluralism, specifically with an eye toward laying metaphysical groundwork for an account of divine naming inspired by Avicenna. I try to show (1) that Avicenna’s pluralism is well-motivated as a metaphysical thesis and (2) that it offers substantive philosophical support for a correlatively pluralist approach to divine naming. My argument proceeds by identifying two influential objections to ontological pluralism, and then offering replies to these objections with the help of Avicenna. The (...) first objection pertains to pluralism as a position in general metaphysics, whereas the second pertains to pluralism as a position in theological epistemology or divine naming. To the extent that these replies are successful, I argue that Avicennian pluralism is compelling on both counts as a philosophical position. (shrink)

Philosophers who study conspiracy theories have increasingly addressed the questions of where conspiracy theories come from, what such theories do, and what to do about them. This essay serves as a commentary on the answers to these questions offered by contributors to this special issue.

This chapter examines a variety of discussions in the Shenzi Fragments that might lead one to think that there is some sort of morality undergirding its political philosophy including: 1) positive references to conventional virtues, 2) an advocacy of according with the overarching Way, and 3) the development of a form of state consequentialism. While it would be possible to construct moral reasons in support of each of these three positions, the Shenzi Fragments does not do so. Rather, as this (...) chapter argues, the justification of each of these positions arises from practical considerations of political order. The normativity at work, then is political in nature, rather than moral. (shrink)

In the Western philosophic tradition, virtue theory has rarely been extended to the political realm. There is a long tradition that advocates the role of virtue in ethical theory, but the implications of this tradition for political theory have largely been neglected. However, in the Chinese tradition, we very early on see the use of virtue-based theories not only in ethics but in political thought as well. Indeed, one of the most sophisticated early Confucian philosophers, Xúnzǐ 荀子 (fl. 298–238 BCE), (...) believes that a virtue-based political theory is a natural extension of his virtue-based ethical theory. At the same time, a prominent anti-Confucian political philosopher, Hán Fēizǐ 韓非子, was diametrically opposed to allowing virtue, or, indeed, any other moral quality, serve as the basis for political theory, arguing instead that a clear set of laws should serve as the fundamental basis. Therefore, this tradition offers us a very clear debate on the problems and promise of a virtue politics. This debate is not only of historical interest, however. To the extent that contemporary philosophers interested in the possibility of extending virtue theory to the political realm take themselves to be prescribing for everyone, as opposed to simply for those within their own cultural background, they must be willing to take into account other traditions that have wrestled with similar issues. In early China we not only see a version of virtue politics, we also see a sophisticated debate about its viability. And, while Xúnzǐ himself may not be capable of answering all of Hán Fēizǐ’s objections, analyzing this debate affords us the opportunity to see how and where a particular conception of virtue politics succeeds and fails, providing contemporary philosophers not only with a set of problems that must be overcome but also with a promising way forward. (shrink)

Alasdair MacIntyre ao realizar uma série de críticas à moralidade e filosofia moral modernas e contemporâneas defende a tese de que o desacordo moral e a ausência de justificação racional para a moralidade é fruto do abandono do elemento teleológico da ética, especialmente do abandono da ética aristotélica, o que o leva a propor a retomada da ética teleológica de Aristóteles. Essa retomada é justificada com a teoria da racionalidade das tradições, por meio da afirmação de que o modo tradicional (...) de investigação é o melhor e que a tradição aristotélico-tomista corresponde a uma tradição moral superior às suas rivais. Com sua adesão a essa tradição MacIntyre vai apontar Tomás de Aquino como o teórico que conseguiu reunir todas as características do modo tradicional de investigação moral, integrando a tradição aristotélica e a agostiniana, o que fez com que o próprio MacIntyre se aproximasse e se apropriasse cada vez de elementos fundamentais do Tomismo. O Tomismo de MacIntyre, por sua vez, sofre uma série de críticas e objeções, especialmente em relação às tensões que se estabelecem no interior do pensamento do autor, que em After Virtue prometia um pensamento secular e pragmático. Este trabalho tratará dessa tensão e de algumas críticas direcionadas ao Tomismo de MacIntyre. (shrink)

The story of Anna is a brief description of a faithful prophetess which is consciously paired with the previous and more developed narrative of Simeon. Hannah’s story is significant to the Lukan Gospel and yet her voice, which men and women visiting the temple heard repeatedly, is not articulated by Luke. She has been the topic of much research, in as much as three verses in their context can provide, while no one has sought to let Hannah speak for herself. (...) This article aims to do this by exploring her story within the Lukan narrative, considering prophetesses in the Old Testament, and echoing the dynamics of the Jewish story of Judith with which she is intertextually paired. (shrink)

Recent studies claim that having an analytical cognitive style is correlated with reduced religiosity in western populations. However, in cultural contexts where social norms constrain behavior, such cognitive characteristics may have reduced influence on behaviors and beliefs. We labeled this the ‘constraining environments hypothesis.’ In a sample of 246 Muslims in Turkey, the hypothesis was supported for gender. Females face social pressure to be religious. Unlike their male counterparts, they were more religious, less analytical, and their analytical scores were uncorrelated (...) with religiosity. We had predicted an analogous effect for the comparison between monolingual and bilingual students, since English-proficient students are exposed to a wider social environment. The bilingual students were less religious than the monolingual students, yet they were also less analytical. Thus, being analytical was not the path to lower religiosity for the bilingual students. Cognitive styles need to be studied along with social norms in a variety of cultures, to understand religion-cognition relationships. (shrink)

Cloning - few words have as much potential to grip our imagination or grab the headlines. No longer the stuff of science fiction or Star Wars - it is happening now. Yet human cloning is currently banned throughout the world, and therapeutic cloning banned in many countries. In this highly controversial book, John Harris does a lot more than ask why we are so afraid of cloning. He presents a deft and informed defence of human cloning, carefully exposing the (...) rhetorical and highly dubious arguments against it. He begins with an introduction to what a human clone is, before tackling some of the most common and frequently bizarre criticisms of cloning: Is it really wicked? Can we regulate it? What about the welfare of cloned children? Does it turn human beings into commodities? Dismissing one by one some of the myths about human cloning, in particular that it is degrading and unsafe, he astutely argues that some of our most cherished values, such as the freedom to start a family and the freedom from state control, actually support the case for human cloning. Offering a brave and lucid insight into this ethical minefield, John Harris at last shows that far from ending the diversity of human life or creating a race of super-clones, cloning has the power to improve and heal human life. (shrink)

Connectionist models provide a promising alternative to the traditional computational approach that has for several decades dominated cognitive science and artificial intelligence, although the nature of connectionist models and their relation to symbol processing remains controversial. Connectionist models can be characterized by three general computational features: distinct layers of interconnected units, recursive rules for updating the strengths of the connections during learning, and “simple” homogeneous computing elements. Using just these three features one can construct surprisingly elegant and powerful models of (...) memory, perception, motor control, categorization, and reasoning. What makes the connectionist approach unique is not its variety of representational possibilities or its departure from explicit rule-based models, or even its preoccupation with the brain metaphor. Rather, it is that connectionist models can be used to explore systematically the complex interaction between learning and representation, as we try to demonstrate through the analysis of several large networks. (shrink)

ABSTRACTThis paper restates some of the principal arguments against an automatic preference for the young as advocated by Kappel and Sandøe, arguments many of which have been extant for over a decade but which Kappel and Sandøe largely ignore. It then goes on to demonstrate that Kappel and Sandøe's “indifference test” fails to do the work required of it because it can be met by unacceptable conceptions of justice. The paper develops a number of new arguments against what I have (...) called “ageist” preferences for the young or for those with long life expectancy. Finally I show that Kappel and Sandøe must believe that murdering older people is less morally wrong than murdering the young and that people relying on arguments such as theirs will have to accept the moral respectability of killing the innocent in order to maximise units of lifetime. (shrink)

This article explores three aspects of Masterman's language work and applies them to questions of spiritual intelligence: metaphor, coherence, and ambiguity. First, metaphor, which is ubiquitous in ordinary language, both leads and misleads in religious and scientific understanding. Masterman's case for a “dual-approach” to thinking, both speculative and critical, is explored and tied to concepts of moral-spiritual development per Pierre Hadot and Hannah Arendt. Second, Masterman's work on machine translation presents semantic disambiguation as an emerging coherence wherein one gradually hones (...) in on meaning through features of ordinary language (like redundancy and repetition). This is applied to the problem of comprehending difficult spiritual language, and tied to spiritual stretching and spiritual cartography. Third, Masterman's work with thesauri, rather than relying on words as having fixed meanings, appeals to a concept of semantic spaces, nebulae of variously interconnected meanings. This is constructed into an exhortation to reambiguate overfamiliar religious language, to reinvest one's quotidian surroundings with spiritual meaning through defamilarization. (shrink)

People reject ‘paradoxical’ inferences, such as: Luisa didn't play music; therefore, if Luisa played soccer, then she didn't play music. For some theorists, they are invalid for everyday conditionals, but valid in logic. The theory of mental models implies that they are valid, but unacceptable because the conclusion refers to a possibility inconsistent with the premise. Hence, individuals should accept them if the conclusions refer only to possibilities consistent with the premises: Luisa didn't play soccer; therefore, if Luisa played a (...) game then she didn't play soccer. Two experiments corroborated this prediction for three sorts of ‘paradox’, including a disjunctive paradox. (shrink)

This paper demonstrates how argumentation schemes can be used in decision support systems that help clinicians in making treatment decisions. The work builds on the use of computational argumentation, a rigorous approach to reasoning with complex data that places strong emphasis on being able to justify and explain the decisions that are recommended. The main contribution of the paper is to present a novel set of specialised argumentation schemes that can be used in the context of a clinical decision support (...) system to assist in reasoning about what treatments to offer. These schemes provide a mechanism for capturing clinical reasoning in such a way that it can be handled by the formal reasoning mechanisms of formal argumentation. The paper describes how the integration between argumentation schemes and formal argumentation may be carried out, sketches how this is achieved by an implementation that we have created and illustrates the overall process on a small set of case studies. (shrink)

Who deserves credit for epistemic successes, and who is to blame for epistemic failures? Extreme views, which would place responsibility either solely on the individual or solely on the individual’s surrounding environment, are not plausible. Recently, progress has been made toward articulating virtue epistemology as a suitable middle ground. A socio-environmentally oriented virtue epistemology can recognize that an individual’s traits play an important role in shaping what that individual believes, while also recognizing that some of the most efficacious individual traits (...) have to do with how individuals structure their epistemic environments and how they respond to information received within these environments. I contribute to the development of such an epistemology by introducing and elucidating the virtue of epistemic exactingness, which is characterized by a motivation to regulate the epistemically significant conduct of others. (shrink)